Publications

Relevant Publications 2004

•  Barberá A and Domínguez MC. Características e inmunopatogénesis de la artritis reumatoide. Estado actual en el tratamiento. Biotecnología aplicada 21[4], 189-201. 2004. Rev.

•  Guillén G, Hermida L, Márquez G, Lazo L, Páez R, Martínez R, García-Suárez J, López C, Espinosa R, Muné M, Rodríguez R, Guzmán G, Ramírez R, Rodríguez R, Álvarez M, Rosario D, Vázquez S, Sierra B, Soto Y, Valdés K, Pupo M, García G, Serrano T, Moreno ME, and Pumariega T. Potencialidad inmunogénica de la proteína de la envoltura del virus Dengue 4 expresada por vía recombinante en Pichia pastoris. Biotecnología aplicada 21[3], 175-7. 2004. Rep

•  Hernández-Hernández H. Twenty-Seventh Annual Conference on Shock. Biotecnología aplicada 21[3], 158-9. 2004. t: Rep

•  Porras DN, Cosme K, Aldana L, Bacardí D, Valenzuela C, Milá L, Suárez-Alba J, Amaya R, Vázquez A, García-Suárez J, Lobaina Y, Alonso M, Aguilar JC, Muzio V, and Merino N. Determinación del potencial irritante de un candidato vacunal nasal que combina al antígeno de superficie del virus de la hepatitis B con el antígeno de la nucleocápsida. Biotecnología Aplicada 21[3], 143-7. 2004. Inv

•  García del Barco D and Montero E. Redundant regulatory mechanisms in autoimmune diseases: the example of experimental autoimmune encephalomyelitis. Biotecnología aplicada 21[4], 202-12. 2004. Rev

•  Rodríguez-Alfonso A, Nápoles MC, Costales D, Corbera J, Morales B, Cabrera JC, Reynaldo I, Cartaya O, Varela O, Hernández G, Bordallo E, Hernández R, and Hormanza J. Influencia del medio de cultivo y los rizobios en la nodulación de la soya y el frijol. Biotecnología Aplicada 21[4], 260-2. 2004. Rep

•  Dueñas-Carrera S and Musacchio A. Hepatitis C virus: new lights on the horizon. Biotecnología aplicada 21[4], 254-6. 2004. Rep

•  Fernández-Ortega C, Bello Y, and Mesa C. Recent findings on innate and adaptive immunity. Biotecnología aplicada 21[4], 250-3. 2004. Rep

•  Morera V. EULAR 2004: magna cita de la Reumatología. Biotecnología aplicada 21[4], 234-8. 2004. Rep

•  Tuñón MA, Sánchez1 K, Castañeda F, Sánchez E, Noa E, Ruibal IJ, Dubed M, and Álvarez G. Desescalado del proceso de producción de HEBERTRANS® para su validación viral. Biotecnología aplicada 21[4], 229-233. 2004. 
Inv

•  Pons T, Pereda CM, Rodríguez HM, Álvarez RI, Pérez-Tenorio G, Orozco M, Fernández MA, Escobar X, and Camacho R. Péptidos sintéticos de dominios funcionales del receptor de estrógeno humano para la producción de anticuerpos policlonales y monoclonales. Gaceta Mex Oncol 3[2], 21-7. 2004.

•  Pupo E, Hardy E, Phillips NJ, Gibson BW, and Apicella MA. Matrix-assisted laser desorption/ionization-time of flight-mass spectrometry of lipopolysaccharide species separated by slab-polyacrylamide gel electrophoresis: high-resolution separation and molecular weight determination of lipooligosaccharides from Vibrio fischeri strain HMK. Electrophoresis 25[14], 56-64. 2004.

•  Porras D, Bacardí D, Aldana L, Meriño N, Amaya R, Suárez J, Váazquez A, Valenzuela C, Rojo G, Milá L, Castillo J, Cosme K, and Duarte CA. Evaluación toxicológica en ratas Sprague-Dawley de Interleuquina-2 y del candidato vacunal FPCR3//terapia combinada en pacientes con SIDA. Rev Toxicol 21[1], 31-7. 2004.

•  Nodarse H, Iznaga- N, Viera D, Rodríguez-Gómez H, Fernández-Fernández H, Blanco Y, Viada C, and López-Saura P. Interferon alpha-2b as adjuvant treatment of recurrent respiratory papillomatosis in Cuba: National Programme (1994-1999 report).  J Laryngol Otol 118[9], 681-7. 2004.

•  Marrero J, González LJ, Sánchez A, Ayala M, Paz-Lago D, González W, Fallarero A, Castellanos-Serra L, and Coto O. Effect of high concentration of Co (II) on Enterobacter liquefaciens strain C-1: a bacterium highly resistant to heavy metals with an unknown genome. Proteomics 4[5], 1265-79. 2004.

•  López M, Ruiz Ll, Reyes N, Sotolongo J, Pujol V, and Aroche K. Long-term stabilization of a freeze-dried recombinant streptokinase without serum albumin. J Clin Pharm Ther 29, 367-73. 2004.

•  Llerena LD, Quirós JJ, Sainz B, Valdés JA, Zorio B, Villanueva LH, Filgueiras CE, Cabrera F, Echarte JC, Pérez del Todo JM, Guerrero I, López L, García EJ, Nadal B, Betancourt BY, Díaz-Rojo G, García AI, and López-Saura P. Angiographic patency study of an albumin-free recombinant streptokinase formulation in acute myocardial infarction. J Pharm Sci 7[3], 372-7. 2004.

•  Limonta M, del Monte A, Díaz L, Aldama Casas Y, and Márquez G. Immobilisation of HEP-1 by covalent attachment to aldehyde-agarose gels. Int J Biotechnol 6[4], 361-6. 2004.

•  Martínez C, Talavera A, Rojas G, Moreno E, Krengel U, Olsson LL, Mier E, and Angstrom J. Structure and molecular interactions of a unique antitumor antibody specific for N-glycolyl GM3. J Biol Chem 279[7], 5597-603. 2004.

•  Rodríguez-Valle M, Méndez L, Valdés M, Redondo M, Montero C, Vargas M, Lleonart R, Pérez-Barrios H, Seoane G, Serrano E, Boué O, Lodos J, Machado H, Borroto C, and Joglar M. Integrated control of Boophilus microplus ticks in Cuba based on vaccination with the anti-tick vaccine Gavac TM. Exp Appl Acarol 34[3-4], 375-82. 2004.

•  Hardy E and Castellanos-Serra L. "Reverse-staining" of biomolecules in electrophoresis gels: analytical and micropreparative applications. Anal Biochem 328[1], 1-13. 2004.

•  González-Pérez I, González-González YJ, Viña-Rodríguez A, Armas A, and Solís RL. The usefulness of UMELOSA hepatitis C virus qualitative kit as supplemental test for confirmation of hepatitis C virus infection. Rev Soc Bras Med Trop 37[1], 25-7. 2004.

•  González LJ, Cremata JA, Guanche Y, Ramos Y, Triguero A, Cabrera G, Montesino R, Huerta V, Pons T, Boué O, Farnos O, and Rodríguez M. The cattle tick antigen, Bm95, expressed in Pichia pastoris contains short chains of N- and O-glycans. Arch Biochem Biophys 432[2], 205-11. 2004.

•  García-García I, González-Delgado CA, Valenzuela CM, Hernández-Bernal F, Ferrero-Bibilonia J, Soto-Hernández R, Cervantes-Llano M, Ducongé J, Correa-Fernández A, Olivera-Ruano L, and López-Saura P. Bioequivalence of two recombinant interferon alpha-2b liquid formulations in healthy male volunteers. Drugs 5[5], 271-80. 2004.

•  García R, Aguiar J, Alberti E, de la Cuetara K, and Pavón N. Bone marrow stromal cells produce nerve growth factor and glial cell line-derived neurotrophic factors. Biochem Biophys Res Commun 316[3], 753-4. 2004.

•  Besada V, Castellanos-Serra L, Fichtner I, and Becker M. Differential protein expression pattern in tamoxifen-sensitive and -resistant breast cancer xenografts. Int J Clin Pharmacology and Therapeutics 42[11], 632-4. 2004.

•  Fernández-Santana V, Cardoso F, Rodríguez A, Carmenate T, Peña L, Valdés Y, Hardy E, Mawas F, Heynngnezz L, Rodríguez MC, Figueroa I, Chang J, Toledo ME, Musacchio A, Hernández I, Izquierdo M, Cosme K, Roy R, and Verez V. Antigenicity and immunogenicity of a synthetic oligosaccharide-protein conjugate vaccine against Haemophilus influenzae type b. Infect Immunol 72[12], 7115-23. 2004.

•  Fernández-Ortega C, Dubed M, Ramos Y, Navea L, Álvarez G, Lobaina L, López L, Casillas D, and Rodríguez L. Non-induced leukocyte extract reduces HIV replication and TNF secretion. Biochem Biophys Res Commun 325[3], 1075-1081. 2004.

•  Fernández-de-Cossío J, González LJ, Betancourt L, Ramos Y, Huerta V, Besada V, Padrón G, Satomi Y, Minamino N, and Takao T. Automated interpretation of mass spectra of complex mixtures by matching of isotope peak distributions. Rapid Commun Mass Spectrom 18[20], 2465-72. 2004.

•  Carmona E, Vargas D, Borroto CJ, López J, Fernández A., Arencibia AD, and Borrás-Hidalgo O. cDNA-AFLP analysis of differential gene expression during the interaction between sugarcane and Puccinia melanocephala . Plant Breeding [123], 499-501. 2004.

•  Cabrera G, Cremata JA, Valdés R, García R, González Y, Montesino R, Gómez H, and González M. Influence of culture conditions on the N-glycosylation of a monoclonal antibody specific for recombinant hepatitis B surface antigen. Biotechnol Appl Biochem 40[1], 1-10. 2004.

•  Borrás O, Borroto J, Pujol M, Carmona E, and Arencibia AD. Identification of sugarcane genes induced during colonization by Ustilago scitaminea and Dreschlera sacchari . Physiol Molec Plant Pathol 65[1], 1-6. 2004.

•  Bello-Rivero I, Cervantes M, Torres Y, Ferrero J, Rodríguez E, Pérez J, García I, Díaz G, and López-Saura P. Characterization of the immunoreactivity of anti-interferon alpha antibodies in Myasthenia gravis patients. Epitope mapping. J Autoimmun 23[1], 63-73. 2004.

•  Basabe L, Domínguez I, and Chávez FP. Cloning and sequence analysis of the Candida utilis HIS3 gene. Biomol Eng 21[1], 15-20. 2004.

•  Bacardí D, Merino N, Cosme K, Porras D, Carreras I, Díaz G, Suárez J, Aldana L, Amaya R, Mosqueda O, Vázquez A, Cruz Y, Milá L, and Hernández L. Evaluación de la toxicidad subcrónica del Factor Estimulador de Colonias de Granulocitos. Rev CENIC: Ciencias Biológicas 35[3], 203-9. 2004.

•  Arrieta JG, Sotolongo M, Menéndez C, Alfonso D, Trujillo LE, Soto M, Ramírez R, and Hernández L. A type II protein secretory pathway required for levansucrase secretion by Gluconacetobacter diazotrophicus . J Bacteriol 186[15], 5031-9. 2004.

•  Álvarez A, Martín A, Falcón V, de la Rosa MC, González-Blanco S, Guillén G, and Silva R. Association of the P64k dihydrolipoamide dehydrogenase to the Neisseria meningitidis membrane. Biotecnología Aplicada 21[3], 137-42. 2004.

•  Aldana L, Cosme K, Porras D, Merino N, Valenzuela CM, Amaya R, Suárez J, Vázquez A, Bacardí D, Milá L, and Sánchez K. Ensayo de primera ola del Factor de Transferencia (HEBERTRANS). Rev CENIC: Ciencias Biológicas 35[3], 197-201. 2004.

•  Aguilar JC, Lobaina Y, Muzio V, García D, Pentón E, Iglesias E, Pichardo D, Urquiza D, Rodríguez D, Silva D, Petrovsky N, and Guillén G. Development of a nasal vaccine for chronic hepatitis B infection that uses the ability of hepatitis B core antigen to stimulate a strong Th1 response against hepatitis B surface antigen. Immunol Cell Biol 82[5], 539-46. 2004.

•  Acosta-Rivero N, Rodríguez-Alfonso A, Musacchio A, Falcón V, Martínez G, Guerra I, Paz-Lago D, Morera Y, de la Rosa MC, Morales-Grillo J, Dueñas-Carrera S, and Suárez VM. In vitro assembly into virus-like particles is an intrinsic quality of Pichia pastoris derived HCV core protein.  Biochem Biophys Res Commun 325[1], 68-74. 2004.

•  Acosta-Rivero N, Rodríguez-Alfonso A, Musacchio A, Falcón V, Chávez L, Morales-Grillo J, Dueñas-Carrera S, and Suárez VM. Nucleic acid binding properties and intermediates of HCV core protein multimerization in Pichia pastoris.  Biochem Biophys Res Commun 323[3], 926-31. 2004 .

•  Leyva A, Hernández , González T, Sánchez JC, Franco A, Delgado I, Montañez M, and Valdés R. Standardization and validation of an alkaline phosphatase-linked immunoassay to quantify a plant-derived antibody directed against the hepatitis B virus surface antigen. Biochem Biophys Res Commun 325[5], 1438-42. 2004.

•  Fuentes A, Ramos PL, Ayra C, Rodríguez M, Ramírez NI, and Pujol M. Development of a highly efficient system for assessing recombinant gene expression in plant cell suspensions via Agrobacterium tumefaciens transformation. Biotechnol Appl Biochem 39[Pt 3], 355-61. 2004 .

•  Dueñas-Carrera S. DNA vaccination against hepatitis C. Curr Opin Mol Ther 6[2], 146-50. 2004 .

•  Fernandez-de-Cossio J, González LJ, Betancourt L, Ramos Y, Huerta V, Amaro A, Besada V, Padrón G, Yoshinori Satomi, Minamino N, and Takao T. Isotopica: a tool for the calculation and viewing of complex isotopic envelopes. Nucleic Acids Res 32[12], 3779. 2004 .

•  Arenal A, Pimentel R, García C, Pimentel E, and Alestrom P. The SV40 T antigen nuclear localization sequence enhances nuclear import of vector DNA in embryos of a crustacean (Litopenaeus schmitti). Gene 337[1], 71-7. 2004.

•  Guerra-Vallespi M, Colas M, Garay HE, Reyes O, and Araña MJ. Differential regulation of Th1/Th2 in relevant tissues for sepsis pathogenesis with a Limulus anti-LPS factor-derived peptide increases survival in Gram-positive sepsis. Int Immunopharmacol 4[10-11], 1343-51. 2004.

•  Ducongé J, Prats PA, Valenzuela CM, Aguilera A, Rojas I, Hardy E, Becquer MA, Álvarez D, Estrada L, Alfonso-Ortiz S, García-Pulpeiro O, and Fernández-Sánchez E. Topical disposition of two strengths of a 125I-rhEGF jelly in rat skin wounds. Biopharm Drug Dispos 25[5], 193-201. 2004.

•  Galbán-Rodríguez E. Nonviral DNA vectors for immunization and therapy: design and methods for their obtention. J Mol Med 82[8], 500-9. 2004.

•  Aguilar JC. Vaccine adjuvants: Current state and future trends. Immunol Cell Biol 82, 488-6. 2004. Special Feature.

•  Ramos PL, Fuentes AD, Peral R, Pujol M, Quintana Q, Castrillo G, Guevara-Gonzalez RG, and Rivera-Bustamante RF. Identification of the minimal sequence required for vascular-specific activity of Tomato mottle Taino virus replication-associated protein promoter in transgenic plants. Virus Res 102[2], 125-32. 2004.

•  Fernández CI, Alberti E, Mendoza Y, Martínez L, Collazo J, Rosillo JC, and Bauza JY. Motor and cognitive recovery induced by bone marrow stem cells grafted to striatum and hippocampus of impaired aged rats: functional and therapeutic considerations. Ann N Y Acad Sci 1019[1], 48-52. 2004.

•  Cremata JA, Montesino R, Cabrera G, Mata M, and García R. Desarrollo de un sistema combinado de perfil cromatográfico y espectrometría de masas fluoróforo asistido para la caracterización de la N-gliocosilación de glicoproteínas. Biotecnología Aplicada 21[2], 108-12. 2004. Rep.

•  Menéndez C, Hernández-García L, Banguela A, and País JM. Functional production and secretion of the Gluconacetobacter diazotrophicus fructose-releasing exo-levanase (LsdB) in Pichia pastoris. Enzyme Microb Technol 34[5], 446-52. 2004.

•  Martínez CP, Rodríguez A, Ramírez R, Hernández-García L, Tarbouriech N, Ortíz M, Taylor E, and Davies GJ. Crystallization and preliminary X-ray diffraction analysis of levansucrase (LsdA) from Gluconacetobacter diazotrophicus SRT4. Acta Crystallogr D Biol Crystallogr 60[(Pt 1)], 181-3. 2004.

•  Acosta-Rivero N, Dueñas-Carrera S, Álvarez-Lajonchere L, and Morales-Grillo J. HCV core protein-expressing DNA vaccine induces a strong class I-binding peptide DTH response in mice. Biochem Biophys Res Commun 314[3], 781-6. 2004.

•  Borrás-Hidalgo O. Basic insight in plant-pathogen interaction. Biotecnología Aplicada 21[1], 1-4. 2004. Rev.

•  Herrera A, Galbán-Rodríguez E, Sández B, Pichardo D, Musacchio A, Hayes O, Quintana D, Vázquez-Blomquist DM, Soria Y, Fernández JR, Duarte CA, Román CA, Hernández T, and Valiente PA. Diseño, construcción y evaluación de cuatro familias de vectores de ADN plasmídicos para transferencia génica en humanos. Biotecnología Aplicada 21[1], 40-3. 2004. Rep

•  González S, Nazábal C, Rao KV, Reyes O, Garay HE, Caballero E, Álvarez-Obregón JC, Sardinas G, and Silva R. Cell mediated immune response elicited in mice after immunization with the P64k meningococcal protein: epitope mapping. FEMS Immunol Med Microbiol 42[2], 233-9. 2004.

•  Reyes O, Torrens I, Ojalvo AG, Seralena A, and Garay HE. Profiling the immune responses of human patients treated with recombinant streptokinase after myocardial infarct. Mol Divers 8[3], 251-6. 2004.

•  Dueñas M, Nazábal M, and Novoa LI. From genetic to genomic and to functional genomic. Goals and future perspectives. Biotecnología Aplicada 21[1], 31-3. 2004. Rep

•  Dueñas-Carrera S, Viña-Rodríguez A, Martínez R, Álvarez-Lajonchere L, Álvarez-Obregón JC, Marante J, Pérez-Beloborodova A, Mosqueda O, Martínez G, and Morales-Grillo J  . Immunization with a DNA vaccine encoding the hepatitis-C-virus structural antigens elicits a specific immune response against the capsid and envelope proteins in rabbits and Macaca irus (crab-eating macaque monkeys). Biotechnol Appl Biochem 39[Part.2], 249-55. 2004.

•  Boué O, Farnós O, González A, Fernández R, Acosta JA, Valdés R, González LJ, Guanche Y, Izquierdo G, Suárez M, Domínguez I, Machado H, Rodríguez-Valle M, and Lleonart R. Production and biochemical characterization of the recombinant Boophilus microplus Bm95 antigen from Pichia pastoris. Exp Appl Acarol 32[1-2], 119-28. 2004.

•  Carmenate T, Canaán-Haden L, Álvarez-Acosta A, Delgado M, González-Blanco S, Menéndez T, Rodes L, and Guillén G. Effect of conjugation methodology on the immunogenicity and protective efficacy of meningococcal group C polysaccharide-P64k protein conjugates. FEMS Immunol Med Microbiol 40[3], 193-9. 2004.

•  Díaz-Ruano A, Martínez CP, Taylor CY, Rodríguez-Alfonso A, Pajón R, Espinosa R, and Silva R. Estimating molecular mass of the complex formed by the B transferrin binding protein (TbpB, Strain CU385) from  Neisseria meningitidis and human transferrin using gel filtration chromatography and dynamic light scattering. Biotecnología Aplicada 21[3], 153-7. 2004. Inv

•  Ramos PL , Díaz L, Peral R, Fuentes AD, Pujol M, Echemendía AL, and González G. First report of SIDA golden yellow vein virus infecting SIDA species in Cuba . Plant Pathol 53[2], 234. 2004.

•  Perea SE, Reyes O, Puchades Y, Mendoza O, Vispo NS, Torrens I, Santos A, Silva R, Acevedo B, López E, Falcón V, and Alonso DF. Antitumor effect of a novel proapoptotic peptide that impairs the phosphorylation by the protein kinase 2 (casein kinase 2). Cancer Res 64[19], 7127-9. 2004.

•  Pons T, Martínez CP, Hernández L, and Naumoff DG. Three acidic residues are at the active site of a beta-propeller architecture in glycoside hydrolase families 32, 43, 62, and 68. Proteins 54[3], 424-32. 2004.

•  Hermida L, Lazo L, Silva R, Zulueta A, López C, Martín J, Valdés I, Guillén G, Rodríguez R, Bernardo L, del Rosario D, and Guzmán MG. A fragment of the envelope protein from dengue-1 virus, fused in two different sites of the meningococcal P64k protein carrier, induces a functional immune response in mice. Biotechnol Appl Biochem 39[Pt 1], 107-14. 2004.

•  Hermida L, Rodríguez R, Lazo L, Silva R, Zulueta A, Chinea G, López C, Guzmán MG, and Guillén G. A dengue-2 Envelope fragment inserted within the structure of the P64k meningococcal protein carrier enables a functional immune response against the virus in mice. J Virol Methods 115[1], 41-9. 2004.

•  López C, Sánchez J, Hermida L, Zulueta A, and Márquez G . Cysteine mediated multimerization of a recombinant dengue E fragment fused to the P64k protein following immobilized metal ion affinity chromatography. Protein Expr Purif 34[2], 176-82. 2004.

•  Díaz BR, Abrahantes MC, González M, Valdés R, and Pérez ME. Establishment and validation of an immunoenzymatic assay to determine mouse IgG levels based on a rat monoclonal antibody. Biochem Biophys Res Commun 317[2], 614-7. 2004.

•  Mainet D, Galván JA, Sorell L, Torres MB, Abdo A, Castellano R, Padrón N, Palenzuela D, and Novoa LI. Preliminary evaluation of a rapid, qualitative one step immunoassay of cardiac Troponin I in the acute myocardial infarction diagnosis. Invest Clin  45[3], 221-42. 2004.

•  País JM, García Y, Licor L, Besada V, Castellanos-Serra L, Cabello CI, Hernández L, Mansur M, Hidalgo A, Támbara Y, Abrahantes MC, del Toro Y, Valdés J, Martínez E, and Plana L. Improving the expression of mini-proinsulin in Pichia pastoris. Biotechnol Lett 26[16], 1269-72. 2004.

---

Relevant Publications 2003

• Aguiar JA, Castellanos MR, Fernández CI, Almaguer W, Mejías C, and Varela A. Evaluation of the neurorestorative effects of the murine beta-nerve growth factor infusions in old rat with cognitive deficit. Biochemical and biophysical research communications 312[4], 867-872. 2003 .

• Beldarraín A, Acosta-Contreras N, Betancourt L, González LJ, and Pons T. Enzymic, spectroscopic and calorimetric studies of a recombinant dextranase expressed in Pichia pastoris . Biotechnology and applied biochemistry 38[Pt 3], 211-21. 2003 .

• Berlanga-Acosta J, Bashir O, Fitzgerald AJ, Playford RJ, and Goodlad RA. Effect of epidermal growth factor administration on intestinal cell proliferation, crypt fission and polyp formation in multiple intestinal neoplasia (Min) mice. Clinical science 105[3], 323-30. 2003.

• Berlanga-Acosta J, Ray EC, Avissar NE, Vukcevic D, Toia L, Ryan CK, and Sax HC. Growth hormone and epidermal growth factor together enhance amino acid transport systems B(0,+) and A in remnant small intestine after massive enterectomy (1). Journal of surgical research 115[1], 164-70. 2003.

• Betancourt BY, López-Saura P, and Parellada-Blanco J. Streptokinase for the treatment of acute ischaemic stroke: towards better strategies. CNS drugs central nervous system 17[5], 371. 2003.

• Bringas R, Manke T, and Vingron M. Correlating protein-DNA and protein-protein interaction networks. Journal of molecular biology 333[1], 75-85. 2003.

• González LJ, Castellanos-Serra L, Díaz M, Moro A, Perea SE, Santos A, Paz-Lago D, Padrón G, Badock V, Otto A, Muller EC, Kostka S, and Wittmann-Liebold B. Identification of nuclear proteins of small cell lung cancer cell line H82: An improved procedure for the analysis of silver-stained proteins. Electrophoresis 24[1-2], 237-52. 2003.

• Guerra-Vallespi M, Álvarez-Obregón JC, Rodríguez-Alonso I, Montero T, Garay H, Reyes O, and Arana M. A Limulus anti-LPS factor-derived peptide modulates cytokine gene expression and promotes resolution of bacterial acute infection in mice. International journal of immunopharmacology 3[2], 247-56. 2003.

• Hermida L, Lazo L, Guillén G, Guzmán MG, Rodríguez R, Rodríguez R, Álvarez M, Mune M, Rosario D, Valdés K, Vásquez S, Martínez R, Serrano T, Páez J, Espinosa R, and Pumariega T. Induction of neutralizing antibodies and partial protection from viral challenge in Macaca fascicularis immunized with recombinant dengue 4 virus envelope glycoprotein expressed in Pichia pastoris . The american journal of tropical medicine and hygiene 69[2], 129-34. 2003.

• Hernández-Bernal F, Latini R, Staszewsky L, Maggioni AP, Marino P, Tognoni G, Labarta V, Gramenzi S, Bianchi F, Sarcina G, Cremonesi G, Nicolosi GL, and Geraci E. Beneficial effects of angiotensin-converting enzyme inhibitor and nitrate association on left ventricular remodeling in patients with large acute myocardial infarction: the Delapril Remodeling after Acute Myocardial Infarction (DRAMI) trial. American heart journal 146[1], 133. 2003 .

• Herrera A, Bhardwaj D, Kushwaha A, Puri SK, Singh N, and Chauhan VS. DNA prime-protein boost immunization in monkeys: efficacy of a novel construct containing functional domains of Plasmodium cynomolgi CS and TRAP. FEMS immunology and medical microbiology 39[3], 241-50. 2003.

• Izquierdo M, Cremata JA, Yuen CT , Storring PL , Tiplady RJ, Wait R, Gee CK, Gerson P, and Lloyd P. Relationships between the N-glycan structures and biological activities of recombinant human erythropoietins produced using different culture conditions and purification procedures. British journal of haematology 121[3], 511-26. 2003.

• Lobaina Y, García D, Abreu N, Muzio V, and Aguilar JC. Mucosal immunogenicity of the hepatitis B core antigen. Biochemical and biophysical research communications 300[3], 745-50 . 2003.

• López-Saura P. Thrombolysis with recombinant streptokinase in Cuba . British medical journal 326[7386], 22448. 2003.

• López-Saura P, Berlanga-Acosta J, Dorticos E, Pavón V, Jaime JC, Reboredo M, and Hernández P. Successful application of epidermal growth factor for treatment of hemorrhagic cystitis after bone marrow transplantation. Bone marrow transplant 31[7], 615-6. 2003.

• Martín A. The P64k Neisseria meningitidis dihydrolipoamide dehydrogenase participates in catalysis of the pyruvate dehydrogenase multienzyme complex. Biotecnología aplicada 20[2], 102-6. 2003.

• Márquez G, García J, Guillén G, Mune M, Rodríguez R, Ramírez R, Soto Y, Sierra B, Rodríguez Roche R, and Guzmán MG. Carboxy-terminally truncated Dengue 4 virus envelope glycoprotein expressed in Pichia pastoris induced neutralizing antibodies and resistance to Dengue 4 virus challenge in mice. Archives of virology 148[11], 2267-73. 2003.

• Ojalvo AG, Seralena A, Vázquez R, Santiago NF, Silva R, Puchades Y, Sorell L, López-Saura P, Alí A, Herrera L , Montequín JF, Aldama A, Alfonso MA, Simón R, and Seuc A. Therapeutic angiogenesis following intramuscular gene transfer of vascular endothelial growth factor 121 in a dog model of hindlimb ischemia. Electronic journal of biotechnology 6[3]. 2003.

• Pons T, Gómez R, Chinea G, and Valencia A. Beta-propellers: associated functions and their role in human diseases. Current medicinal chemistry 10[6], 505-24. 2003.

• Pujol M, Coll Y, Marisa Ruiz, Pedro Castanera, Félix Ortega, Hernández CA, Alfonso-Rubí J, Armas R, Pérez M, and González A. Proteolytic gut activities in the rice water weevil, Lissorhoptrus brevirostris Suffrian (Coleoptera: curculionidae). Archives of insect biochemistry and physiology 53[1], 19-29. 2003.

• Pupo E, Hardy E, Gulin S, and Schweda EKH. Linking mass spectrometry and slab-polyacrylamide gel electrophoresis by passive elution of lipopolysaccharides from reverse-stained gels: analysis of gel-purified lipopolysaccharides from Haemophilus influenza e strain Rd. Analytical chemistry 75[18], 4918-24. 2003.

• Pérez-Hernández E, Sánchez O, Lämmerhofer M, Lindner W, and Kenndler E. Estimation and comparison of Z-potentials of silica-based anion-exchange type porous particles for capillary electrochromatography from electrophoretic and electroosmotic mobility. Electrophoresis 24[2], 390-8. 2003.

• Ramírez NI, Rodríguez-Hernández M, Ayala M, Cremata JA, Pérez M, Martínez A, Linares M, Hevia Y, Páez R, Valdés R, Gavilondo JV, and Selman-Housein G. Expression and characterization of an anti-(hepatitis B surface antigen) glycosylated mouse antibody in transgenic tobacco ( Nicotiana tabacum ) plants and its use in the immunopurification of its target antigen. Biotechnology and applied biochemistry 38[ Pt 3], 223-30. 2003.

• Valdés R, Reyes B, Álvarez T, García J, Montero JA, Figueroa A, Gómez LR, Padilla SA, Abrahantes MC, Dorta L, Fernández D, Mendoza O, Pujol M, Borroto C, and Brito JE. Hepatitis B surface antigen immunopurification using a plant-derived specific antibody produced at large scale. Biochemical and biophysical research communications 310 [3], 742-7. 2003.

• Valenzuela CM, López-Saura P, ul-Haq N, Hasnain SS, Umar M, and Abbas Z. Immunogenicity of 10 and 20 microgram hepatitis B vaccine in a two-dose schedule. Vaccine 21[23], 3179-85. 2003.

• Vázquez-Blomquist DM, Iglesias E, González EE, and Duarte CA. The HIV-1 chimeric protein CR3 expressed by poxviral vectors induces a diverse CD8+ T cell response in mice and is antigenic for PBMCs from HIV+ patients. Vaccine 22[2], 145-55. 2003.

• Zulueta A, Hermida L, Lazo L, Valdés I, López C, Silva R, Martín J, Guillén G, Rodríguez R, Rosario D , and Guzmán MG. The fusion site of envelope fragments from each serotype of Dengue virus in the P64k protein, influence some parameters of the resulting chimeric constructs. Biochemical and biophysical research communications 308[3], 619-26. 2003.

• Atul Sinha, M.R.C.P., Jeremy M.D. Nightingale, F.R.C.P., Kevin P. West, F.R.C.Path., Jorge Berlanga-Acosta, Ph.D., and Raymond J. Playford, F.R.C.P. Epidermal Growth Factor Enemas with Oral Mesalamine for Mild-to-Moderate Left-Sided Ulcerative Colitis or Proctitis. N Engl J Med. 2003 Jul 24;349(4):350-7.

elevant Publications 2003back to top