Area |
Technology Platform |
Goal |
The CIGB is able to offer capabilities and expertise in plant genetic engineering and downstream process for the expression and recovery of recombinant proteins from transgenic plants. |
Description |
A long experience in plant transformation from several species has been accumulated at the CIGB. From tobacco to cereal crops, transgenic plants have been obtained and the molecular and biochemical characterization performed. Recombinant antibody procedures are also well known and routinely used in our institution. Cloning of whole antibody chains or fragments in plant transformation vectors and obtaining of transgenic plants expressing functional antibodies or fragments has been achieved. Experience on genetic manipulation for protein sorting to subcellular compartments is also available. Downstream procedures for the recovery of recombinant antibody and antibody fragments from transgenic plants have been established at the CIGB. A solid experience and tradition in purification, quality control and assurance of recombinant proteins is available. The expression of vaccine antigens in plants is also in focus. Regulatory approval for the industrial production and use of a monoclonal antibody from plants has been granted to the CIGB.
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Patent Status |
Intellectual Property Rights on regulation of foreign gene expression in plants is available. |
Project Status |
Platform technology with National Registration granted.
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Type of collaboration requested |
Strategic alliance in biopharming. Contract manufacturing.
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Competitives advantages Milestones |
The use of plants as expression systems for recombinant proteins is currently receiving a lot of attention all over the world. Among other advantages, lower production costs, virtually unlimited scale-up potential, and lack of susceptibility to known human or animal diseases make the plant system a very attractive alternative for this purpose .
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Host Insitutions |
Center for Genetic Engineering and Biotechnology (CIGB). Ave 31, e/158 y 190 Cubanacán, Playa. PO Box 6996, Havana, 10600, Cuba. Tel. (53-7) 2712397; 2716022. Fax. (53-7) 336008; 2718070. E-mail: ernesto.lopez@cigb.edu.cu.
Web site: http://gndp.cigb.edu.cu
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Project code:
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BIO/CIGB/2008-18
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