Agriculture area |
Veterinary vaccines |
Goal |
Development of a recombinant vaccine candidate against swine classical fever based on a recombinant antigen transiently expressed in goats. |
Description |
Swine classical fever is a highly contagious viral disease affecting swine, which has been classified under strict declaration status by the International Office of Epizooties.
The infectious agent responsible is a virus CSFV (previously called hog cholera virus) of the genus Pestivirus in the family Flaviviridae. In this virus E2 glycoprotein from the viral capside is considered highly immunogenic and able to release neutralizing antibodies against CSFV.
In many countries, SCF eradication program included a ban on classical swine fever vaccines made from live virus (a potential source of new infection), the development of a rapid test to diagnose CSF and the development of disinfectants that would kill the virus. The eradication program also developed methods to control the spread of the disease including preventive slaughter of animals a highly expensive option.
There are only two recombinant vaccines available in the market against CSF, but considering the complex of the technology and the antigen low expression level, both are expensive.
In our Project we showed the capacity of our recombinant antigen expressed in goat transiently transformed with adenovirus to protect challenged animals against CSF and maintain them healthy, alive and virus free.
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Patent Status |
Two granted patents protect the goat productive system and the expressed recombinant protein fused to an immunological booster. |
Project Status |
Research, proof of concept proved.
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Type of collaboration requested |
Interest in establishing evaluation and commercialization agreements.
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Competitives advantages Milestones |
High protection using the recombinant antigen when compared with classical vaccines based in attenuated virus.
We have been able to demonstrate that our formulation with the antigen has a very high termo-stability, protecting the animals even when they where maintained during 7 days at 37ºC.
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Host Insitutions |
Center for Genetic Engineering and Biotechnology (CIGB). Ave 31, e/158 y 190 Cubanacán, Playa. Apdo. 6996, La Habana, 10600, Cuba . Tel. (53-7) 2712397; 2716022. Fax. (53-7) 2736008; 2718070. email: ernesto.lopez@cigb.edu.cu .
Web site: http://gndp.cigb.edu.cu |
Project code:
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BIO/CIGB/2008-20
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